HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pivaloyl chloride → HCID 67995076, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pivaloyl chloride | HCID 62493 | — |
| Reactant | HCID 51346777 | HCID 51346777 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 67995076 | HCID 67995076 | 47% |
Reaction Steps
To a solution of 48 (150 mg, 0.33 mmol) and DMAP (4 mg, 0.033 mmol) in pyridine (1.0 ml) was added pivaloyl chloride (57 μl, 0.46 mmol) as dropwise at room temperature and stirred for 10 h. The crude product was purified by prep HPLC (C18) to provide the titled compound (83 mg, 47%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586550B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-1a255daf9a7841d28d9c6fce78d784c6 |
| Source note | uspto-grants-2013_11 |