1-Iodo-3,5-dimethylbenzene → HCID 58319093, compound

Participants

Reaction Steps

The title compound was prepared from methyl 3-(4-ethynylphenyl)propanoate (99 mg, 0.53 mmol) and 1-iodo-3,5-dimethylbenzene (0.08 mL, 0.55 mmol) according to the general procedure IC to give 128 mg (83%) of an orange solid after purification by flash chromatography (SiO2, EtOAc/hexanes, 1:5). Rf: 0.59 (EtOAc:hexanes, 2:5); 1HNMR (CDCl3) δ 7.21-7.19 (m, 2H), 7.07-7.05 (m, 2H), 6.90-6.89 (m, 2H), 6.78-6.77 (m, 1H), 2.72-2.67 (t, 2H, J=7.8 Hz), 2.42-2.37 (t, 2H, J=7.8 Hz), 2.05 (s, 6H); 13CNMR (CDCl3) δ 173.1, 140.7, 137.8, 131.7, 130.1, 129.2, 128.3, 122.9, 121.4, 89.4, 88.6, 51.6, 35.4, 30.8, 21.1; ESI-MS m/z 315.1 (MNa+).

Provenance & Evidence