7-Chloro-4-iodoquinoline → HCID 54758023, compound

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The title compound was prepared from methyl 3-(4-ethynylphenyl)propanoate (54 mg, 0.29 mmol) and 7-chloro-4-iodoquinoline (93 mg, 0.32 mmol) according to the general procedure IC to give 54 mg (54%) of a beige solid after purification by flash chromatography (SiO2, EtOAc:PE, 1:4). Rf=0.06 (EtOAc:PE, 1:4); 1H NMR (CDCl3) δ 8.88 (d, J=4.8 Hz, 1H), 8.27 (d, J=9.0 Hz, 1H), 8.11 (m, 1H), 7.59-7.52 (m, 4H), 7.28-7.25 (m, 2H), 3.69 (s, 3H), 3.01 (t, J=7.8 Hz, 2H), 2.67 (t, J=7.8 Hz, 2H); 13C NMR (CDCl3) δ 172.9, 150.8, 148.5, 142.4, 135.8, 132.1, 129.9, 128.8, 128.6, 128.1, 127.4, 126.1, 123.5, 119.9, 99.2, 84.4, 51.7, 35.2, 30.9; ESI-MS m/z 372.1 (M+Na+).

Provenance & Evidence