反应详情

The title compound was prepared from methyl 2-(4-ethynylphenyl)cyclopropanecarboxylate (80 mg, 0.40 mmol) and 1-iodo-3-methylbenzene (60 μL, 0.47 mmol) according to the general procedure IF to give 42 mg (36%) of a pale yellow solid after purification by flash chromatography (SiO2, EtOAc:PE, 1:9): Rf=0.43 (EtOAc:PE, 1:4); 1H NMR (CDCl3) δ 7.43 (d, J=8.3 Hz, 2H), 7.37-7.30 (m, 2H), 7.23 (t, J=7.6 Hz, 1H), 7.14 (d, J=7.6 Hz, 1H), 7.06 (d, J=8.2 Hz, 2H), 3.72 (s, 3H), 2.61-2.45 (m, 1H), 2.35 (s, 3H), 1.92 (ddd, J=8.5, 5.3, 4.3 Hz, 1H), 1.63 (dt, J=9.9, 5.0 Hz, 1H), 1.33 (ddd, J=8.4, 6.5, 4.7 Hz, 1H); 13C NMR (CDCl3) δ 173.6, 140.3, 138.0, 132.2, 131.7, 129.1, 128.6, 128.2, 126.2, 123.1, 121.5, 89.7, 88.8, 52.0, 26.2, 24.2, 21.2, 17.2; ESI-MS m/z 313.1 (M+Na+).