1-Indanone, 4-bromo- → HCID 45112277, compound

Participants

Reaction Steps

The title compound was prepared from methyl 3-(4-ethynylphenyl)propanoate (94 mg, 0.50 mmol) and 4-bromo-2,3-dihydro-1H-inden-1-one (116 mg, 0.55 mmol) according to the general procedure IF to give 110 mg (69%) of an yellow solid after purification by flash chromatography (SiO2, EtOAc:PE, 1:5): Rf=0.34 (EtOAc:PE, 1:2); 1H NMR (CDCl3) δ 7.76-7.68 (m, 2H), 7.55-7.43 (m, 2H), 7.38 (t, J=7.6 Hz, 1H), 7.22 (d, J=8.3 Hz, 2H), 3.68 (s, 1H), 3.29-3.21 (m, 2H), 2.98 (t, J=7.7 Hz, 3H), 2.77-2.71 (m, 2H), 2.65 (t, J=7.7 Hz, 2H); 13C NMR (CDCl3) δ 206.6, 173.0, 157.1, 141.5, 137.3, 136.8, 131.8 128.5, 127.5, 123.3, 122.3, 120.7, 94.8, 85.3, 51.7, 36.1, 35.3, 30.8, 25.5; ESI-MS m/z 341.1 (M+Na+).

Provenance & Evidence