4-Bromopyridinium chloride → HCID 54757837, compound

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The title compound was prepared from methyl 3-(4-ethynylphenyl)propanoate (94 mg, 0.50 mmol) and 4-bromopyridine hydrochloride (108 mg, 0.55 mmol) according to the general procedure IC to give 72 mg (54%) of a white solid after purification by flash chromatography (SiO2, EtOAc:PE, 1:5). Rf=0.26 (EtOAc:PE, 1:1); 1H NMR (CDCl3) δ 8.52 (dd, J=4.5, 1.5 Hz, 2H), 7.45-7.39 (m, 2H), 7.29 (dd, J=4.5, 1.6 Hz, 2H), 7.14 (d, J=8.3 Hz, 2H), 3.60 (s, 3H), 2.90 (t, J=7.7 Hz, 2H), 2.57 (t, J=7.7 Hz, 2H); 13C NMR (CDCl3) δ 172.0, 148.8, 141.0, 131.0, 130.5, 127.5, 124.5, 119.0, 92.9, 85.5, 50.7, 34.3, 29.8; ESI-MS m/z 288.1 (M+Na+).

Provenance & Evidence