2-Iodophenol → HCID 58319090, compound

Participants

Reaction Steps

The title compound was prepared from methyl 3-(4-ethynylphenyl)propanoate (102 mg, 0.53 mmol) and 2-iodophenol (130 mg, 0.58 mmol) according to the general procedure IF to give 19 mg (13%) of a white solid after purification by flash chromatography (SiO2, EtOAc:PE, 1:10). Rf=0.28 (EtOAc:PE, 1:5); 1H NMR (CDCl3): δ 7.79 (dt, J=8.3 Hz, 2.0 Hz, 2H), 7.56 (d, J=1.0 Hz, 1H), 7.50 (d, J=1.0 Hz, 1H), 7.29-7.21 (m, 3H), 6.98 (d, J=1.0 Hz, 1H), 3.68 (s, 3H), 2.99 (t, J=7.8 Hz, 2H), 2.60 (t, J=7.8 Hz, 2H); 13C NMR (CDCl3): δ 173.2, 155.9, 154.8, 141.1, 129.3, 128.7, 128.8, 125.1, 124.1, 122.9, 120.9, 111.1, 100.9, 51.6, 35.5, 30.7; ESI-MS m/z 303.1 (M+Na+).

Provenance & Evidence