HRID2043045

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID18937

1-Nonyne

C9H16

结构：O=S(=O)(c1ccccc1)n1cc(I)c(-c2cccnc2)n1

HCID57548066

未命名化合物

HCID178442470

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCC#Cc1cn(S(=O)(=O)c2ccccc2)nc1-c1cccnc1

HCID67283963

未命名化合物

收率 80%

HCID178442740

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3283

Diethyl Ether

C4H10O

PROCEDURE

实验过程

Compound 44C was prepared following the procedure as described for the synthesis of compound 44A (see Scheme 9) using non-1-yne and 3-(1-phenylsulfonyl-4-iodo-1H-pyrazol-3-yl)-pyridine (36B). (flash chromatography with diethyl ether/PE 1/1) to afford 3-(1-phenylsulfonyl-4-non-1-ynyl-1H-pyrazol-3-yl)-pyridine (43C) as an oil (80%). (TLC diethyl ether Rf 0.44).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3d71f12f2ef641549786b1fb2d418b8e
来源数据集: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08586606B2
来源说明: uspto-grants-2013_11

反应 SMILES

[C:1]([C:7]1[C:8]([C:12]2[CH2:13][N:14](C)[CH2:15][CH2:16][CH:17]=2)=[N:9][NH:10][CH:11]=1)#[C:2][CH2:3][CH2:4][CH2:5][CH3:6].[CH:19]#[C:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27].[C:28]1([S:34]([N:37]2[CH:41]=[C:40](I)[C:39]([C:43]3[CH:44]=[N:45][CH:46]=[CH:47][CH:48]=3)=[N:38]2)(=[O:36])=[O:35])[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>C(OCC)C>[C:1]([C:7]1[C:8]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)=[N:9][NH:10][CH:11]=1)#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:19][CH2:20][CH3:21].[C:28]1([S:34]([N:37]2[CH:41]=[C:40]([C:19]#[C:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[C:39]([C:43]3[CH:44]=[N:45][CH:46]=[CH:47][CH:48]=3)=[N:38]2)(=[O:36])=[O:35])[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1