HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1'-Carbonyldiimidazole → 4-(4-Chlorophenyl)piperidine-1-carboxylic acid [4-(5-methylhexahydropyrrolo[3,4-b]pyrrol-1-yl)phenyl]amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 4-(4-Chlorophenyl)piperidine | HCID 1203613 | — |
| Reactant | 5-Methyl-octahydropyrrolo(3,4-b)pyrrole | HCID 16228899 | — |
| Reactant | HCID 68427891 | HCID 68427891 | — |
| Product | 4-(4-Chlorophenyl)piperidine-1-carboxylic acid [4-(5-methylhexahydropyrrolo[3,4-b]pyrrol-1-yl)phenyl]amide | HCID 73041232 | — |
Reaction Steps
5-Methyloctahydropyrrolo[3,4-b]pyrrole (EP 0 393 424) was initially converted as described in Example 3 into 4-(5-methylhexahydropyrrolo[3,4-b]pyrrol-1-yl)-phenylamine and then reacted with carbonyldiimidazole and subsequently with 4-(4-chlorophenyl)piperidine. The product with the molecular weight of 439.01 (C25H31ClN4O); MS (ESI): 439 (M+H+) was obtained in this way.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586609B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-d6b203f2f71c4f7ba45552d857098886 |
| Source note | uspto-grants-2013_11 |