HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → 4-(piperazin-1-yl)-N-(pyrimidin-4-yl)benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 2-(Di-tert-butylphosphino)biphenyl | HCID 2734215 | — |
| Reactant | 4-bromo-N-(pyrimidin-4-yl)benzenesulfonamide | HCID 59465704 | — |
| Reactant | sodium 2-methylpropan-2-olate | HCID 178418730 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-(piperazin-1-yl)-N-(pyrimidin-4-yl)benzenesulfonamide | HCID 59465635 | — |
Reaction Steps
Synthesized according to general procedure 4. The reaction was set up with 1.6 mmol 4-bromo-N-(pyrimidin-4-yl)benzenesulfonamide, 16.0 mmol piperazine, 0.12 mmol Pd2(dba)3, 0.15 mmol of 2-(di-t-butylphosphino)biphenyl, 10 mmol of NaO-tBu and 12 ml, toluene. For the purification, 10% MeOH in CH2Cl2 without the addition of triethylamine was used as a solvent system. Yield: 430 mg (84%). LC/MS (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)), m/z: M+1 obs=320.2; tR=0.42 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586589B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-4efbfa3b96de4d949c9059545e96d1e9 |
| Source note | uspto-grants-2013_11 |