HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → HCID 59465931, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 1,2,4-Thiadiazol-5-amine--hydrogen chloride (1/1) | HCID 22014543 | — |
| Reactant | (r)-4-(3-Methylpiperazin-1-yl)-n-(1,2,4-thiadiazol-5-yl)benzenesulfonamide | HCID 59465674 | — |
| Reactant | 7-Chloro-indole-1-acetic acid | HCID 67082699 | — |
| Product | HCID 59465931 | HCID 59465931 | 288.7% |
Reaction Steps
Synthesized according to general procedure 9, method B. The reaction was set up with (R)-4-(3-methylpiperazin-1-yl)-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide (400 mg, 1.2 mmol), 2-(7-chloro-1H-indol-1-yl)acetic acid (250 mg, 0.15 mmol), HATU reagent (390 mg, 0.15 mmol), sodium bicarbonate (151 mg, 1.8 mmol), and DMF/CH2Cl2—1/1 (1.0 mL) to obtain the desired amide as a white solid (230 mg, 36% yield). LC/MS (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)), m/z: M+1 obs=531.0; tR=3.21 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586589B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-0a12a576a2b04e8ca0e5bd64198736be |
| Source note | uspto-grants-2013_11 |