Bromine → 2-Bromo-2'-chloroacetophenone

HRID 2043210Notes

Reaction equation

HRID 2043210 reaction equation
[Br:1]Br.[Cl:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10](=[O:12])[CH3:11]>C(O)(=O)C>[Br:1][CH2:11][C:10]([C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[Cl:3])=[O:12]

Participants

4

Reactant 2

HCID 24408BromineHCID 72864Ethanone, 1-(2-chlorophenyl)-

Product 1

HCID 27357852-Bromo-2'-chloroacetophenone

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Bromine (3.8 mL, 65 mmol) was added dropwise to a solution of 1-(2-chloro-phenyl)-ethanone (10 g, 65 mmol) in acetic acid (75 mL) at 0° C. The mixture was then warmed to room temperature and stirred overnight. The mixture was evaporated to dryness and used in the next step without further purification.

Workup

  1. customThe mixture was evaporated to dryness
  2. customused in the next step without further purification

Sources & evidence

ORD record
ord-f0d86d972dbf48dea84631f42c76ea0d
Source dataset
uspto-grants-2013_11
Patent number
US08586615B2

Reaction notes

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