反应详情

To 5,6-dichloro-1-methyl-2-isopropenyl-1H-benzimidazole (2.5 g) in acetone (30 mL) and water (6 mL) at room temperature was added trichloroisocyanuric acid (845 mg). The resulting mixture was stirred at room temperature for 18 h. The reaction mixture was quenched with water, extracted with EtOAc, and dried over Na2SO4. After removal of the desiccant by filtration, concentration yielded an orange crude oil. The crude product was purified by flash chromatography (10%-40% EtOAc/hexanes) to yield the title compound as a yellow solid.

1. customThe reaction mixture was quenched with water
2. extractionextracted with EtOAc
3. dry with materialdried over Na2SO4
4. customAfter removal of the
5. filtrationdesiccant by filtration, concentration
6. customyielded an orange crude oil
7. customThe crude product was purified by flash chromatography (10%-40% EtOAc/hexanes)