Methanol → HCID 59682281, compound

HRID 2043291Notes

Reaction equation

HRID 2043291 reaction equation
[BH4-].[Na+].CO.[Cl:5][C:6]1[C:24]([Cl:25])=[CH:23][C:9]2[N:10]([CH2:18][C:19](=[O:22])[CH2:20][CH3:21])[C:11]([CH2:13][C:14]([F:17])([F:16])[F:15])=[N:12][C:8]=2[CH:7]=1>O>[Cl:5][C:6]1[C:24]([Cl:25])=[CH:23][C:9]2[N:10]([CH2:18][CH:19]([OH:22])[CH2:20][CH3:21])[C:11]([CH2:13][C:14]([F:15])([F:16])[F:17])=[N:12][C:8]=2[CH:7]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 4311764Sodium borohydrideHCID 44430223HCID 44430223, compound

Product 1

HCID 59682281HCID 59682281, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Sodium borohydride (11.16 mg, 0.2949 mmol) was added into methanol (5 mL). After the bubbling ceased, 1-[5,6-dichloro-2-(2,2,2-trifluoro-ethyl)-benzoimidazol-1-yl]-butan-2-one (19170-168) (100 mg, 0.2949 mmol) was added. The resulting mixture was stirred at room temperature for 1 hour. The resulting mixture was poured into water and then extracted with EtOAc. The organic layer was dried over anhydrous MgSO4. The solvent was distilled out under reduced pressure to yield the title compound as an off-white solid.

Workup

  1. extractionextracted with EtOAc
  2. dry with materialThe organic layer was dried over anhydrous MgSO4
  3. distillationThe solvent was distilled out under reduced pressure

Sources & evidence

ORD record
ord-c9f6304c90f446df8e0f73687e795c1e
Source dataset
uspto-grants-2013_11
Patent number
US08586616B2

Reaction notes

Loading…