Tetrahydrofuran → HCID 59728133, compound

Participants

Reaction Steps

[3-tert-Butyl-dimethyl-silanyloxymethyl]phenyl]-(3H-imidazol-4-ylmethyl)-isopropyl-amine (0.724 g, 2 mmol) was dissolved in tetrahydrofuran (20 ml) and tetrabutylammonium fluoride solution (4 ml, 1M) in tetrahydrofuran was added. After stirring the mixture at room temperature overnight the solvent was evaporated and the residue was purified by flash chromatography (SiO2, eluent: ethyl acetate) to yield a colourless gum, (0.252 g, 51%); MS (ISP): 246.4 ((M+H)+.).

Provenance & Evidence