HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2043394Generated: October 26, 2026
2-(Di-tert-butylphosphino)biphenyl → HCID 86659376, compound
https://huagongshe.com/reaction/2043394
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-(Di-tert-butylphosphino)biphenyl | HCID 2734215 | — |
| Reactant | (S)-1-(4-Fluorophenyl)-ethylamine | HCID 2779063 | — |
| Reactant | Sodium t-butoxide | HCID 23676156 | — |
| Reactant | 2,6-Dichloro-4-(1-methyl-1H-pyrazol-4-yl)pyridine | HCID 86659375 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 86659376 | HCID 86659376 | 64.4% |
Reaction Steps
257 mg of 2,6-dichloro-4-(1-methyl-1H-pyrazol-4-yl)pyridine obtained by Step 1, 164 mg of (S)-(−)-1-(4-fluorophenyl)ethylamine, 66 mg of 2-(di-t-butylphosphino)biphenyl, 271 mg of sodium t-butoxide and 25 mg of palladium acetate were added in turn to 6 ml of degassed toluene, and the mixture was stirred at 85° C. for 2 hours under argon atmosphere. The reaction solution was purified by silica gel column chromatography to obtain 240 mg of the objective compound as pale yellow powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08586591B2 |
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| Source dataset | uspto-grants-2013_11 |
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| ORD ID | ord-8e56c4b0eaca4fd98d6eda64dc3393af |
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| Source note | uspto-grants-2013_11 |
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