HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 46866218, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | Methylamine tetrahydrofuran | HCID 66615946 | — |
| Reactant | HCID 67007881 | HCID 67007881 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 46866218 | HCID 46866218 | 54.2% |
Reaction Steps
80 mg of (S)-2-[1-(4-Fluorophenyl)ethylamino]-6-(pyrazin-2-ylamino)nicotinic acid was dissolved in 1 ml of tetrahydrofuran, 86 mg of O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate salt (HBTU) and 59 mg of triethylamine were added thereto. The mixture was stirred at room temperature for 30 minutes, and then 119 μl of 2M methylamine/tetrahydrofuran solution was added thereto, and the mixture was stirred for 5 hours. The reaction solution was purified by silica gel column chromatography to obtain 45 mg of the objective compound as white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586591B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-02c31e31b0694b599307e65c51b06d3c |
| Source note | uspto-grants-2013_11 |