Methanol → HCID 131731048, compound

HRID 2043565Notes

Reaction equation

HRID 2043565 reaction equation
C[O:2][NH:3][CH2:4][C:5]([NH:7][C@H:8]([C:14]([OH:16])=[O:15])[CH2:9][CH2:10][CH2:11][CH2:12][NH2:13])=[O:6].CO.[OH-].[Na+]>O>[OH:2][NH:3][CH2:4][C:5]([NH:7][C@H:8]([C:14]([OH:16])=[O:15])[CH2:9][CH2:10][CH2:11][CH2:12][NH2:13])=[O:6]

Participants

5

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 131731049HCID 131731049, compound

Product 1

HCID 131731048HCID 131731048, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a magnetically stirred solution of MeO-GlyLys [ε-CBz] [α-Lys] [Boc]2 (1.0 g, 1.47 mmol), methanol (32 ml) and water (16 ml) was added 1M aq. NaOH solution (3 ml) at Rt. The reaction and product isolation were carried out according to the method described in Example 13.vi to afford HO-GlyLys [ε-CBz] [α-Lys] [Boc]2 (942 mg, 96%) as a colourless foam.

Workup

  1. customThe reaction and product isolation

Sources & evidence

ORD record
ord-7aabf563b6554baead96e1b675b5a11a
Source dataset
uspto-grants-2013_11
Patent number
US08586705B2

Reaction notes

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