HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 20437Generated: October 28, 2026
Water → 1-Fluoro-3-((E)-2-nitro-vinyl)-5-propoxy-benzene
https://huagongshe.com/reaction/20437
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Nitromethane | HCID 6375 | — |
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Reactant | 3-Fluoro-5-propoxybenzaldehyde | HCID 86236800 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 1-Fluoro-3-((E)-2-nitro-vinyl)-5-propoxy-benzene | HCID 68558231 | 69.8% |
Reaction Steps
Add ammonium acetate (2.63 g, 34.08 mmol) to 3-fluoro-5-propoxy-benzaldehyde (2.25 g, 12.35 mmol) and nitromethane (3.09 g, 50.63 mmol) in acetic acid (41 mL) at room temperature and heat in 140° C. oil bath for 3 hours. Cool to room temperature and pour into water. Extract with ethyl acetate, dry over magnesium sulfate, filter and concentrate to afford 1.94 g (69.8%) of the desired compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07745438B2 |
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| Source dataset | uspto-grants-2010_06 |
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| ORD ID | ord-a207859cfb484bf3b0098ee913e5b2b4 |
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| Source note | uspto-grants-2010_06 |
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