Triethylamine → N,N-dimethyl-3-(trifluoromethyl)-1H-pyrazole-1-sulfonamide

Participants

Reaction Steps

To a solution of 3-trifluoromethylpyrazole (5.0 g, 36 mmol), triethylamine (7.0 mL, 50 mmol) in dichloromethane (40 mL) was added N,N-dimethylsulfamoyl chloride (5.5 mL, 51 mmol) and the reaction mixture was warmed to reflux for 2 days. The reaction mixture was cooled to ambient temperature and filtered through a pad of silica gel using dichloromethane as an eluent. The resulting solution was then concentrated under reduced pressure to give an amber residue. The residue was dissolved in diethyl ether and washed with water. The extract was then dried over MgSO4 and concentrated under reduced pressure giving 8.71 g of the title compound. This compound was of sufficient purity to use in subsequent reactions.

Provenance & Evidence