Hydrochloric Acid → 2-[1-[[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolecarboxylic acid

Participants

Reaction Steps

A solution of ethyl-2-[1-[[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolecarboxylate (13.0 g, 30.2 mmol) (i.e. the product of Example 19, Step B) in 60 mL of methanol was cooled to 0° C. and treated with a 1 N aqueous NaOH solution (36.3 mL, 36.3 mmol). The reaction mixture was allowed to warm to room temperature, and stirred for 5 h. The reaction mixture was cooled again to 0° C. and treated with 1 N aqueous hydrochloric acid (36.3 mL, 36.3 mmol). The resulting precipitate was filtered, washed with water and dried in a vacuum oven at 100° C. to give 10.95 g of the title compound as a white solid.

Provenance & Evidence