Hydrochloric Acid → HCID 178448381, compound

Participants

Reaction Conditions

Reaction Steps

Hydrochloric acid (13 g) and 10% palladium on carbon (5.5 g) was added to a solution of mono-benzyloxycarbonyl-L-valine ganciclovir (50 g) in 23% aqueous iso-propanol (Iso-propanol:water::500 mL:150 mL). The reaction mixture was hydrogenated at about 25° C. to 40° C. under hydrogen pressure of 0.5-1 kg/cm2 for about 1 hour. After completion of the reaction, the reaction mass was filtered and washed with iso-propanol:water mixture (Iso-propanol:water::45 mL:5 mL). Iso-propanol (500 mL) was added over a period of about 1 hour. The reaction mass was cooled to 0° C., maintained at about 0° C. to about −5° C. for about 1 hour, filtered, washed with 10% aqueous iso-propanol solution (50 mL) followed by washing with iso-propanol (50 mL) and dried to obtain valganciclovir hydrochloride (31 g).

Provenance & Evidence