Ammonia → Benzo[b]thiophene-3-carboxylic acid (4r)-(1-azatricyclo[3.3.1.13,7]dec-4-yl)-amide hydrochloride

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Reaction Steps

Prepared from (4r)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine hydrochloride and 1-benzothiophene-3-carboxylic acid (Maybridge) according to methods A and C; yield 60 mg, 0.17 mmol (56%): 1H NMR (300 MHz, methanol-d4) δ 2.10-2.30 (m, 5H), 2.48 (s, 2H), 3.50 (d, J=13 Hz, 2H), 3.56 (s, 2H), 3.83 (d, J=13 Hz, 2H), 4.33 (s, 1H), 7.36-7.49 (m, 2H), 7.91-7.96 (m, 1H), 8.28-8.34 (m, 2H); MS (DCI/NH3) m/z 313 (M+H)+; Anal. C18H20N2OS.HCl.0.17H2O: C, H, N.

Provenance & Evidence