Ammonia → 5-(3-Trifluoromethylphenyl)-furan-2-carboxylic acid(4r)-(1-azatricyclo[3.3.1.13,7]dec-4-yl)-amide hydrochloride

Participants

Reaction Steps

Prepared from (4r)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine hydrochloride and 5-[3-(trifluoromethyl)phenyl]-2-furoic acid (Aldrich) according to methods A and C; yield 29 mg, 0.07 mmol (31%): 1H NMR (300 MHz, methanol-d4) δ 2.09-2.30 (m, 5H), 2.52 (s, 2H), 3.50 (d, J=13 Hz, 2H), 3.57 (s, 2H), 3.83 (d, J=13 Hz, 2H), 4.28 (s, 1H), 7.12 (d, J=4 Hz, 1H), 7.34 (d, J=4 Hz, 1H), 7.63-7.69 (m, 2H), 8.10-8.18 (m, 1H), 8.24 (s, 1 H); MS (DCI/NH3) m/z 391 (M+H)+; Anal. C21H21F3N2O2.HCl.0.9H2O: C, H, N.

Provenance & Evidence