Ammonia → HCID 67152099, compound

HRID 2043840Notes

Reaction equation

HRID 2043840 reaction equation
[ClH:1].[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@H:5]3[NH2:12])[CH2:3]1)[CH2:9]2.[S:13]1[CH:17]=[CH:16][CH:15]=[C:14]1[C:18]1[CH:22]=[C:21]([C:23](O)=[O:24])[NH:20][N:19]=1.N>>[ClH:1].[ClH:1].[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@H:5]3[NH:12][C:23]([C:21]3[CH:22]=[C:18]([C:14]4[S:13][CH:17]=[CH:16][CH:15]=4)[NH:19][N:20]=3)=[O:24])[CH2:3]1)[CH2:9]2

Participants

4

Reactant 3

HCID 222AmmoniaHCID 671521221-Azatricyclo[3.3.1.1,3,7]decan-4-amine hydrochlorideHCID 178524131HCID 178524131, compound

Product 1

HCID 67152099HCID 67152099, compound

Procedure

Prepared from (4r)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine hydrochloride and 3-(2-thienyl)-1H-pyrazole-5-carboxylic acid (Specs) according to methods A and C; yield 34 mg, 0.08 mmol (33%): 1H NMR (300 MHz, methanol-d4) δ 2.09-2.29 (m, 6H), 2.45 (s, 2H), 3.49 (d, J=13 Hz, 2H), 3.56 (s, 2H), 3.83 (d, J=13 Hz, 2H), 4.29 (s, 1H), 7.02 (s, 1H), 7.12 (dd, J=5, 4 Hz, 1H), 7.43 (dd, J=4, 1 Hz, 1H), 7.48 (dd, J=5, 1 Hz, 1H); MS (DCI/NH3) m/z 329 (M+H)+; Anal. C17H20N4OS.2HCl.0.15H2O.0.05C4H8O2: C, H, N.

Sources & evidence

ORD record
ord-16ec84bbec724827b7e4f3924f2441cc
Source dataset
uspto-grants-2013_11
Patent number
US08586746B2

Reaction notes

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