Ammonia → HCID 16068046, compound

HRID 2043848Notes

Reaction equation

HRID 2043848 reaction equation
[N:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([C@@H:4]3[NH2:11])[CH2:2]1)[CH2:8]2.[F:12][C:13]1[CH:21]=[CH:20][C:16]([C:17](O)=[O:18])=[CH:15][CH:14]=1.N>>[N:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([C@@H:4]3[NH:11][C:17](=[O:18])[C:16]3[CH:20]=[CH:21][C:13]([F:12])=[CH:14][CH:15]=3)[CH2:2]1)[CH2:8]2

Participants

4

Reactant 3

HCID 222AmmoniaHCID 99734-Fluorobenzoic AcidHCID 156866181-Azatricyclo[3.3.1.1,3,7]decan-4-amine

Product 1

HCID 16068046HCID 16068046, compound

Procedure

Prepared from (4s)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine and 4-fluorobenzoic acid (Aldrich) according to method B; 1H NMR (500 MHz, methanol-d4) δ 1.91-2.04 (m, 4H), 2.12 (s, 1H), 2.31 (d, J=14 Hz, 2H), 2.38 (s, 1H), 3.49 (s, 1H), 3.59 (s, 3H), 3.73 (s, 1H), 3.77-3.89 (m, 1H), 4.38 (s, 1H), 7.20 (t, J=9 Hz, 2H), 7.90 (dd, J=9, 5 Hz, 2H); MS (APCI/NH3) m/z 275 (M+H)+.

Sources & evidence

ORD record
ord-15b3b865096440bc8ac4a4e4a647bcbf
Source dataset
uspto-grants-2013_11
Patent number
US08586746B2

Reaction notes

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