Ammonia → HCID 16068051, compound

HRID 2043854Notes

Reaction equation

HRID 2043854 reaction equation
[N:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([C@@H:4]3[NH2:11])[CH2:2]1)[CH2:8]2.[CH2:12]([O:14][C:15]1[CH:23]=[CH:22][CH:21]=[CH:20][C:16]=1[C:17](O)=[O:18])[CH3:13].N>>[N:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([C@@H:4]3[NH:11][C:17](=[O:18])[C:16]3[CH:20]=[CH:21][CH:22]=[CH:23][C:15]=3[O:14][CH2:12][CH3:13])[CH2:2]1)[CH2:8]2

Participants

4

Reactant 3

HCID 222AmmoniaHCID 672522-Ethoxybenzoic acidHCID 156866181-Azatricyclo[3.3.1.1,3,7]decan-4-amine

Product 1

HCID 16068051HCID 16068051, compound

Procedure

Prepared from (4s)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine and 2-ethoxybenzoic acid (Aldrich) according to method B; 1H NMR (500 MHz, methanol-d4) δ 1.53 (t, J=7 Hz, 3H), 1.94 (s, 1H), 2.02 (d, 2H), 2.11 (d, 1H), 2.20 (d, J=14 Hz, 2H), 2.32 (s, 2H), 3.48 (s, 2H), 3.59 (s, 4H), 4.28 (q, J=7 Hz, 2H), 4.47 (s, 1H), 7.06-7.10 (m, 1H), 7.17 (d, J=8 Hz, 1H), 7.48-7.53 (m, 1H), 7.96 (dd, J=8, 2 Hz, 1H); MS (APCI/NH3) m/z 301 (M+H)+.

Sources & evidence

ORD record
ord-1f6c6fb23629401fb7bfcc76c7f3d9c5
Source dataset
uspto-grants-2013_11
Patent number
US08586746B2

Reaction notes

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