Ammonia → HCID 16068159, compound

HRID 2043857Notes

Reaction equation

HRID 2043857 reaction equation
[N:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([C@@H:4]3[NH2:11])[CH2:2]1)[CH2:8]2.[CH3:12][S:13][C:14]1[CH:22]=[CH:21][C:17]([C:18](O)=[O:19])=[CH:16][CH:15]=1.N>>[N:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([C@@H:4]3[NH:11][C:18](=[O:19])[C:17]3[CH:21]=[CH:22][C:14]([S:13][CH3:12])=[CH:15][CH:16]=3)[CH2:2]1)[CH2:8]2

Participants

4

Reactant 3

HCID 222AmmoniaHCID 832304-(Methylthio)benzoic acidHCID 156866181-Azatricyclo[3.3.1.1,3,7]decan-4-amine

Product 1

HCID 16068159HCID 16068159, compound

Procedure

Prepared from (4s)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine and 4-(methylthio)benzoic acid (Aldrich) according to method B; 1H NMR (500 MHz, methanol-d4) δ 1.92-1.98 (m, 2H), 2.11 (s, 1H), 2.31 (d, J=14 Hz, 2H), 2.38 (s, 2H), 2.52 (s, 3H), 3.49 (s, 2H), 3.59 (s, 4H), 4.37 (s, 1H), 7.31-7.35 (m, 2H), 7.74-7.80 (m, 2H); MS (APCI/NH3) m/z 287 (M+H)+.

Sources & evidence

ORD record
ord-80b9b4648f374702a2a66e08e3d6414d
Source dataset
uspto-grants-2013_11
Patent number
US08586746B2

Reaction notes

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