Ammonia → HCID 16068165, compound

HRID 2043860Notes

Reaction equation

HRID 2043860 reaction equation
[N:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([C@@H:4]3[NH2:11])[CH2:2]1)[CH2:8]2.[C:12]1([C:22](O)=[O:23])[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][CH:13]=1.N>>[N:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([C@@H:4]3[NH:11][C:22]([C:12]3[C:21]4[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=4)[CH:15]=[CH:14][CH:13]=3)=[O:23])[CH2:2]1)[CH2:8]2

Participants

4

Reactant 3

HCID 222AmmoniaHCID 68471-Naphthoic acidHCID 156866181-Azatricyclo[3.3.1.1,3,7]decan-4-amine

Product 1

HCID 16068165HCID 16068165, compound

Procedure

Prepared from (4s)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine and 1-naphthoic acid (Aldrich) according to method B; 1H NMR (500 MHz, methanol-d4) δ 1.94-2.71 (m, 7 H), 3.46-3.93 (m, 6H), 4.56 (s, 1H), 7.50-7.59 (m, 3H), 7.61-7.68 (m, 1H), 7.90-7.96 (m, 1H), 7.97-8.03 (m, 1H), 8.11-8.18 (m, 1H); MS (APCI/NH3) m/z 307 (M+H)+.

Sources & evidence

ORD record
ord-a66bd962d56645cb9eeae57f0ed4d2cf
Source dataset
uspto-grants-2013_11
Patent number
US08586746B2

Reaction notes

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