Ammonia → HCID 16068167, compound

HRID 2043861Notes

Reaction equation

HRID 2043861 reaction equation
[N:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([C@@H:4]3[NH2:11])[CH2:2]1)[CH2:8]2.[C:12](O)(=[O:22])[C:13]1[CH:21]=[CH:20][C:19]2[O:18][CH2:17][O:16][C:15]=2[CH:14]=1.N>>[N:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([C@@H:4]3[NH:11][C:12]([C:13]3[CH:21]=[CH:20][C:19]4[O:18][CH2:17][O:16][C:15]=4[CH:14]=3)=[O:22])[CH2:2]1)[CH2:8]2

Participants

4

Reactant 3

HCID 222AmmoniaHCID 71961,3-Benzodioxole-5-carboxylic acidHCID 156866181-Azatricyclo[3.3.1.1,3,7]decan-4-amine

Product 1

HCID 16068167HCID 16068167, compound

Procedure

Prepared from (4s)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine and piperonylic acid (Aldrich) according to method B; 1H NMR (500 MHz, methanol-d4) δ 1.86-2.63 (m, 7H), 3.46-3.86 (m, 6H), 4.35 (s, 1H), 6.02-6.05 (m, 2H), 6.90 (d, J=8 Hz, 1H), 7.32 (d, J=2 Hz, 1H), 7.44 (dd, J=8, 2 Hz, 1H); MS (APCI/NH3) m/z 301 (M+H)+.

Sources & evidence

ORD record
ord-5941d90bbe9b4fb3873e4995ff7f5039
Source dataset
uspto-grants-2013_11
Patent number
US08586746B2

Reaction notes

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