Ammonia → HCID 67152200, compound

HRID 2043867Notes

Reaction equation

HRID 2043867 reaction equation
[ClH:1].[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@H:5]3[NH2:12])[CH2:3]1)[CH2:9]2.[CH:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[C:15]([C:23](O)=[O:24])[N:14]=1.N>>[ClH:1].[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@H:5]3[NH:12][C:23]([C:15]3[N:14]=[CH:13][C:22]4[C:17]([CH:16]=3)=[CH:18][CH:19]=[CH:20][CH:21]=4)=[O:24])[CH2:3]1)[CH2:9]2

Participants

4

Reactant 3

HCID 222AmmoniaHCID 124656Isoquinoline-3-carboxylic acidHCID 671521221-Azatricyclo[3.3.1.1,3,7]decan-4-amine hydrochloride

Product 1

HCID 67152200HCID 67152200, compound

Procedure

Prepared from (4r)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine hydrochloride and isoquinoline-3-carboxylic acid according to methods A and C. 1H NMR (300 MHz, methanol-d4) δ ppm 2.08-2.34 (m, 5H), 2.51 (s, 2H), 3.42-3.64 (m, 4H), 3.88 (d, J=12.5 Hz, 2H), 4.33 (s, 1H), 7.43 (d, J=8.8 Hz, 2H), 7.68 (d, J=8.8 Hz, 2H), 7.93 (d, J=1.4 Hz, 1H), 8.24 (d, J=1.7 Hz, 1H). MS (DCI/NH3) m/z 308. Anal. Calculated for C19H21N3O.HCl: C, 66.37; H, 6.45; N, 12.22. Found: C, 47.6; H, 5.89; N, 8.71.

Sources & evidence

ORD record
ord-0dcc7872e83b47ec8e7d694625ba6e3c
Source dataset
uspto-grants-2013_11
Patent number
US08586746B2

Reaction notes

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