Ammonia → HCID 67152116, compound

HRID 2043871Notes

Reaction equation

HRID 2043871 reaction equation
[ClH:1].[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@H:5]3[NH2:12])[CH2:3]1)[CH2:9]2.[S:13]1[C:17]2[S:18][CH:19]=[CH:20][C:16]=2[CH:15]=[C:14]1[C:21](O)=[O:22].N>>[ClH:1].[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@H:5]3[NH:12][C:21]([C:14]3[S:13][C:17]4[S:18][CH:19]=[CH:20][C:16]=4[CH:15]=3)=[O:22])[CH2:3]1)[CH2:9]2

Participants

4

Reactant 3

HCID 222AmmoniaHCID 2739591thieno[2,3-b]thiophene-2-carboxylic acidHCID 671521221-Azatricyclo[3.3.1.1,3,7]decan-4-amine hydrochloride

Product 1

HCID 67152116HCID 67152116, compound

Procedure

Prepared from (4r)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine hydrochloride and thieno[2,3-b]thiophene-2-carboxylic acid according to methods A and C. 1H NMR (300 MHz, methanol-d4) δ ppm 2.08-2.34 (m, 5H), 2.51 (s, 2H), 3.42-3.64 (m, 4H), 3.88 (d, J=12.5 Hz, 2H), 4.33 (s, 1H), 7.32 (d, J=5.4 Hz, 1H), 7.53-7.58 (m, 1H), 8.06 (s, 1 H). MS (DCI/NH3) m/z 319. Anal. Calculated for C16H18N2OS2.HCl: C, 54.15; H, 5.40; N, 7.89. Found: C, 54.19; H, 5.25; N, 7.72.

Sources & evidence

ORD record
ord-38bd66e43fa04b3586dd1d2c514248bd
Source dataset
uspto-grants-2013_11
Patent number
US08586746B2

Reaction notes

Loading…