3-Methylbutanal → HCID 178446665, compound

HRID 2043904Notes

Reaction equation

HRID 2043904 reaction equation
[CH:1]1([N:7]([CH2:21][CH2:22][C:23]2[CH:28]=CC=C[CH:24]=2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:13][N:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(=O)CC(C)C.[C:35]([O:39][C@H]1CC[C@H](N)CC1)([CH3:38])([CH3:37])[CH3:36].C(OC(=O)CSC1SC(N)=NC=1)C>>[C:35]([O:39][C@H:4]1[CH2:5][CH2:6][C@H:1]([N:7]([CH2:21][CH2:22][CH:23]([CH3:28])[CH3:24])[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:13][N:14]=2)[CH2:2][CH2:3]1)([CH3:38])([CH3:37])[CH3:36]

Participants

5

Reactant 4

HCID 115523-MethylbutanalHCID 11993791[2-(3-Cyclohexyl-3-phenethylureido)-thiazol-5-ylsulfanyl]-acetic acidHCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 178450580HCID 178450580, compound

Product 1

HCID 178446665HCID 178446665, compound

Procedure

Prepared as described for the synthesis of [2-(3-cyclohexyl-3-phenethyl-ureido)-thiazol-5-ylsulfanyl]-acetic acid using isovaleraldehyde, trans-4-tert-butoxy-cyclohexylamine and (2-amino-thiazol-5-ylsulfanyl)-acetic acid ethyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-43b213d1f8654a8b86454dd97eed5daa
Source dataset
uspto-grants-2013_11
Patent number
US08586614B2

Reaction notes

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