3-Methylbutanal → HCID 178495633, compound

HRID 2043907Notes

Reaction equation

HRID 2043907 reaction equation
[CH:1]1([N:7]([CH2:21][CH2:22][C:23]2[CH:28]=CC=C[CH:24]=2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:13][N:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:29][O:30][CH2:31][C@H]1CC[C@H](N)CC1.C(=O)CC(C)C.C(OC(=O)CSC1SC(N)=NC=1)C>>[CH3:29][O:30][CH2:31][C@H:4]1[CH2:5][CH2:6][C@H:1]([N:7]([CH2:21][CH2:22][CH:23]([CH3:28])[CH3:24])[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:13][N:14]=2)[CH2:2][CH2:3]1

Participants

5

Reactant 4

HCID 115523-MethylbutanalHCID 11993791[2-(3-Cyclohexyl-3-phenethylureido)-thiazol-5-ylsulfanyl]-acetic acidHCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 178495630HCID 178495630, compound

Product 1

HCID 178495633HCID 178495633, compound

Procedure

{2-[3-(trans-4-Methoxymethyl-cyclohexyl)-3-(3-methyl-butyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid was prepared as described for the synthesis of [2-(3-cyclohexyl-3-phenethylureido)-thiazol-5-ylsulfanyl]-acetic acid using, trans-4-methoxymethyl-cyclohexylamine, isovaleraldehyde and (2-amino-thiazol-5-ylsulfanyl)-acetic acid ethyl ester.

Sources & evidence

ORD record
ord-10f2bdf9d2bd436e8f20c6934e3bc431
Source dataset
uspto-grants-2013_11
Patent number
US08586614B2

Reaction notes

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