Butanal → HCID 178449565, compound

HRID 2043910Notes

Reaction equation

HRID 2043910 reaction equation
[CH:1]1([N:7]([CH2:21][CH2:22][C:23]2C=CC=C[CH:24]=2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:13][N:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:29](=O)CCC.C[C@H]1CC[C@H](N)CC1.C(OC(=O)CSC1SC(N)=NC=1)C>>[CH2:21]([N:7]([C@H:1]1[CH2:6][CH2:5][C@H:4]([CH3:29])[CH2:3][CH2:2]1)[C:8](=[O:20])[NH:9][C:10]1[S:11][C:12]([S:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:13][N:14]=1)[CH2:22][CH2:23][CH3:24]

Participants

5

Reactant 4

HCID 261ButanalHCID 11993791[2-(3-Cyclohexyl-3-phenethylureido)-thiazol-5-ylsulfanyl]-acetic acidHCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 178461305HCID 178461305, compound

Product 1

HCID 178449565HCID 178449565, compound

Procedure

Prepared as described for the synthesis of [2-(3-cyclohexyl-3-phenethyl-ureido)-thiazol-5-ylsulfanyl]-acetic acid using butyraldehyde, trans-4-methyl-cyclohexylamine and (2-aminothiazol-5-ylsulfanyl)-acetic acid ethyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-5bff8cb97cac479eaf12fe1b13c20d1f
Source dataset
uspto-grants-2013_11
Patent number
US08586614B2

Reaction notes

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