HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopentanecarbaldehyde → 3-{2-[3-Cyclopentylmethyl-3-(3,4-difluoro-phenyl)-ureido]-thiazole-5-sulfonylamino}-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopentanecarbaldehyde | HCID 70106 | — |
| Reactant | 3,4-Difluoroaniline | HCID 77469 | — |
| Reactant | {2-[3-Cyclopentylmethyl-3-(3,4-difluoro-phenyl)-ureido]-thiazol-4-yl}-acetic acid | HCID 57668246 | — |
| Reactant | (S)-1-(2-aminothiazole-5-sulfonyl)-pyrrolidine-2-carboxylic acid methyl ester | HCID 86629877 | — |
| Reactant | 3-{2-[3-Cyclopentylmethyl-3-(3,4-difluoro-phenyl)ureido]-thiazole-5-sulfonylamino}-propionic acid ethyl ester | HCID 86629879 | — |
| Reactant | 3-(2-Amino-thiazole-5-sulfonylamino)propionic acid ethyl ester | HCID 86629880 | — |
| Product | 3-{2-[3-Cyclopentylmethyl-3-(3,4-difluoro-phenyl)-ureido]-thiazole-5-sulfonylamino}-propionic acid | HCID 57668342 | — |
Reaction Steps
The title compound was prepared via 3-{2-[3-cyclopentylmethyl-3-(3,4-difluoro-phenyl)ureido]-thiazole-5-sulfonylamino}-propionic acid ethyl ester in a similar manner as described for the synthesis of {2-[3-cyclopentylmethyl-3-(3,4-difluoro-phenyl)-ureido]-thiazol-4-yl}-acetic acid, using 3,4-difluoroaniline, cyclopentanecarbaldehyde and 3-(2-amino-thiazole-5-sulfonylamino)-propionic acid ethyl ester the latter prepared in a similar manner as (S)-1-(2-amino-thiazole-5-sulfonyl)-pyrrolidine-2-carboxylic acid methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586614B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-1785a3534c44437cb29e8f8b0ce0df0a |
| Source note | uspto-grants-2013_11 |