HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopentylmethyl-(4-methanesulfonyl-phenyl)-amine → {2-[3-Cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]-thiazole-5-sulfonylamino}-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopentylmethyl-(4-methanesulfonyl-phenyl)-amine | HCID 43453307 | — |
| Reactant | {2-[3-Cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]thiazol-4-yl}-acetic acid | HCID 57668194 | — |
| Reactant | (2-Amino-thiazole-5-sulfonylamino)acetic acid ethyl ester | HCID 86253773 | — |
| Reactant | (S)-1-(2-aminothiazole-5-sulfonyl)-pyrrolidine-2-carboxylic acid methyl ester | HCID 86629877 | — |
| Reactant | {2-[3-Cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)ureido]-thiazole-5-sulfonylamino}-acetic acid ethyl ester | HCID 86629884 | — |
| Product | {2-[3-Cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]-thiazole-5-sulfonylamino}-acetic acid | HCID 57668310 | — |
Reaction Steps
The title compound was prepared via {2-[3-cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)ureido]-thiazole-5-sulfonylamino}-acetic acid ethyl ester in a similar manner as described for the synthesis of {2-[3-cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]-thiazol-4-yl}-acetic acid, using cyclopentylmethyl-(4-methanesulfonyl-phenyl)-amine and (2-aminothiazole-5-sulfonylamino)-acetic acid ethyl ester the latter prepared in a similar manner as (S)-1-(2-amino-thiazole-5-sulfonyl)-pyrrolidine-2-carboxylic acid methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586614B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-b7301125dc854dff9a5034e42835499b |
| Source note | uspto-grants-2013_11 |