HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Aminoacetanilide → 3-{2-[3-(3-Acetylamino-phenyl)-3-cyclopentyl methyl-ureido]-thiazol-5-ylsulfanyl}-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Aminoacetanilide | HCID 7604 | — |
| Reactant | Cyclopentanecarbaldehyde | HCID 70106 | — |
| Reactant | Ethyl 3-[(2-amino-1,3-thiazol-5-YL)sulfanyl]propanoate | HCID 57481428 | — |
| Reactant | {2-[3-Cyclopentylmethyl-3-(3,4-difluoro-phenyl)-ureido]-thiazol-4-yl}-acetic acid | HCID 57668246 | — |
| Reactant | 3-{2-[3-(3-Acetylamino-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-propionic acid ethyl ester | HCID 86629888 | — |
| Product | 3-{2-[3-(3-Acetylamino-phenyl)-3-cyclopentyl methyl-ureido]-thiazol-5-ylsulfanyl}-propionic acid | HCID 67050113 | — |
Reaction Steps
The title compound was prepared via 3-{2-[3-(3-acetylamino-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-propionic acid ethyl ester in a similar manner as described for the synthesis of {2-[3-cyclopentylmethyl-3-(3,4-difluoro-phenyl)-ureido]-thiazol-4-yl}-acetic acid, using N-(3-amino-phenyl)-acetamide, cyclopentanecarbaldehyde and 3-(2-amino-thiazol-5-ylsulfanyl)-propionic acid ethyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586614B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-ba70d98cb673484d86d386470bf1a4fd |
| Source note | uspto-grants-2013_11 |