Ethyl 2-(2-aminothiazol-5-ylthio)acetate → HCID 67050162, compound

HRID 2043949Notes

Reaction equation

HRID 2043949 reaction equation
C([O:3][C:4](=[O:32])[CH2:5][S:6][C:7]1[S:11][C:10]([NH:12][C:13]([N:15](CC2CCCC2)[C:16]2[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=2)=[O:14])=[N:9][CH:8]=1)C.[CH:33]1(CN(C2C=CC(S(C)(=O)=O)=CC=2)C(=O)NC2SC=C(CC(O)=O)N=2)[CH2:37][CH2:36][CH2:35][CH2:34]1.[CH:62]1(CNC2C=CC(C(F)(F)F)=CC=2)CCCC1.C(OC(=O)CSC1SC(N)=NC=1)C>>[CH:33]1([N:15]([C:16]2[CH:17]=[CH:18][C:19]([C:22]([F:23])([F:25])[F:24])=[CH:20][CH:21]=2)[C:13](=[O:14])[N:12]([CH3:62])[C:10]2[S:11][C:7]([S:6][CH2:5][C:4]([OH:3])=[O:32])=[CH:8][N:9]=2)[CH2:37][CH2:36][CH2:35][CH2:34]1

Participants

5

Reactant 4

HCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 53431186N-(Cyclopentylmethyl)-4-(trifluoromethyl)anilineHCID 57668194{2-[3-Cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]thiazol-4-yl}-acetic acidHCID 86629898HCID 86629898, compound

Product 1

HCID 67050162HCID 67050162, compound

Procedure

The title compound was prepared via {2-[3-cyclopentylmethyl-3-(4-trifluoromethyl-phenyl)ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl ester in a similar manner as described for the synthesis of {2-[3-cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]-thiazol-4-yl}-acetic acid, using cyclopentylmethyl-(4-trifluoromethyl-phenyl)-amine and (2-amino-thiazol-5-ylsulfanyl)acetic acid ethyl ester

Sources & evidence

ORD record
ord-11096a18d25d4ed9b7b8e8bac62c2e7d
Source dataset
uspto-grants-2013_11
Patent number
US08586614B2

Reaction notes

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