HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-(2-aminothiazol-5-ylthio)acetate → HCID 57668438, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-(2-aminothiazol-5-ylthio)acetate | HCID 21455623 | — |
| Reactant | {2-[3-Cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]thiazol-4-yl}-acetic acid | HCID 57668194 | — |
| Reactant | 3,4-Difluoro-N-{[4-(trifluoromethyl)cyclohexyl]methyl}aniline | HCID 66961993 | — |
| Reactant | HCID 86629919 | HCID 86629919 | — |
| Product | HCID 57668438 | HCID 57668438 | — |
Reaction Steps
The title compound was prepared via {2-[3-(3,4-difluoro-phenyl)-3-(4-trifluoromethyl-cyclohexylmethyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl ester in a similar manner as described for the synthesis of {2-[3-cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]-thiazol-4-yl}-acetic acid, using 4-trifluoromethyl-cyclohexylmethyl-(3,4-difluorophenyl)-amine and (2-amino-thiazol-5-ylsulfanyl)acetic acid ethyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586614B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-da8fc3c9dda946cfbc47055109f6a262 |
| Source note | uspto-grants-2013_11 |