HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Cyclopentanecarbaldehyde → (2-{3-[3-(Cyclopentanecarbonyl-amino)-phenyl]-3-cyclopentylmethyl-ureido}-thiazol-5-ylsulfanyl)-acetic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Cyclopentanecarbaldehyde | HCID 70106 | — |
| Edukt | N-(3-aminophenyl)cyclopentanecarboxamide | HCID 16774766 | — |
| Edukt | Ethyl 2-(2-aminothiazol-5-ylthio)acetate | HCID 21455623 | — |
| Edukt | {2-[3-Cyclopentylmethyl-3-(3,4-difluoro-phenyl)-ureido]-thiazol-4-yl}-acetic acid | HCID 57668246 | — |
| Edukt | (2-{3-[3-(Cyclopentanecarbonyl-amino)-phenyl]-3-cyclopentylmethyl-ureido}-thiazol-5-ylsulfanyl)-acetic acid ethyl ester | HCID 86629932 | — |
| Produkt | (2-{3-[3-(Cyclopentanecarbonyl-amino)-phenyl]-3-cyclopentylmethyl-ureido}-thiazol-5-ylsulfanyl)-acetic acid | HCID 57668439 | — |
Reaktionsschritte
The title compound was prepared via (2-{3-[3-(cyclopentanecarbonyl-amino)-phenyl]-3-cyclopentylmethyl-ureido}-thiazol-5-ylsulfanyl)-acetic acid ethyl ester in a similar manner as described for the synthesis of {2-[3-cyclopentylmethyl-3-(3,4-difluoro-phenyl)-ureido]-thiazol-4-yl}-acetic acid, using cyclopentanecarboxylic acid (3-amino-phenyl)-amide, cyclopentanecarbaldehyde and (2-amino-thiazol-5-ylsulfanyl)acetic acid ethyl ester.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08586614B2 |
| Quelldatensatz | uspto-grants-2013_11 |
| ORD ID | ord-5ef0e24ff56c4edb892a083bd0712253 |
| Quellennotiz | uspto-grants-2013_11 |