Ethyl 2-(2-aminothiazol-5-ylthio)acetate → HCID 67050167, compound

HRID 2044007Notes

Reaction equation

HRID 2044007 reaction equation
C([O:3][C:4](=[O:34])[CH2:5][S:6][C:7]1[S:11][C:10]([NH:12][C:13]([N:15]([C:22]2[CH:30]=[C:29]3[C:25]([CH2:26][CH2:27][N:28]3[C:31](=[O:33])[CH3:32])=[CH:24][CH:23]=2)[CH2:16][CH:17]2[CH2:21][CH2:20][CH2:19]C2)=[O:14])=[N:9][CH:8]=1)C.[CH:35]1(CN(C2C=CC(S(C)(=O)=O)=CC=2)C(=O)NC2SC=C(CC(O)=O)N=2)CCCC1.C1(CNC2C=C3C(CCN3C(=O)C)=CC=2)CCCC1.C(OC(=O)CSC1SC(N)=NC=1)C>>[C:31]([N:28]1[C:29]2[C:25](=[CH:24][CH:23]=[C:22]([N:15]([CH:16]3[CH2:19][CH2:20][CH2:21][CH2:17]3)[C:13](=[O:14])[N:12]([CH3:35])[C:10]3[S:11][C:7]([S:6][CH2:5][C:4]([OH:3])=[O:34])=[CH:8][N:9]=3)[CH:30]=2)[CH2:26][CH2:27]1)(=[O:33])[CH3:32]

Participants

5

Reactant 4

HCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 57668194{2-[3-Cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]thiazol-4-yl}-acetic acidHCID 669621801-{6-[(Cyclopentylmethyl)amino]-2,3-dihydro-1H-indol-1-yl}ethan-1-oneHCID 86629949{2-[3-(1-acetyl-2,3-dihydro-1H-indol-6-yl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl ester

Product 1

HCID 67050167HCID 67050167, compound

Procedure

The title compound was prepared via {2-[3-(1-acetyl-2,3-dihydro-1H-indol-6-yl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl ester in a similar manner as described for the synthesis of {2-[3-cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]-thiazol-4-yl}-acetic acid, using 1-[6-(cyclopentylmethyl-amino)-2,3-dihydro-indol-1-yl]-ethanone and (2-amino-thiazol-5-ylsulfanyl)acetic acid ethyl ester

Sources & evidence

ORD record
ord-361b9d6ee0284dfda8659e362705371e
Source dataset
uspto-grants-2013_11
Patent number
US08586614B2

Reaction notes

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