Potassium Hydroxide → 1-(BROMOMETHYL)-2-ETHYLBENZENE
Reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9]O)[CH3:2].P(Br)(Br)[Br:12].[OH-].[K+]>CCOCC>[Br:12][CH2:9][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[CH2:1][CH3:2]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
To a solution of (2-ethyl-phenyl)-methanol (3 g, 22 mmol) in ether (10 mL) at 0° C. was added a solution of PBr3 (2.18 g, 8.1 mmol) in ether (3 mL). The reaction mixture was warmed to r.t for 45 minutes and cooled to 0° C. The reaction mixture was treated with 50% aqueous KOH (15 mL) and separated. The organic layer was dried with KOH pellets and concentrated to give 3.9 g of 1-bromomethyl-2-ethyl-benzene.
Workup
- temperatureThe reaction mixture was warmed
- customseparated
- dry with materialThe organic layer was dried with KOH pellets
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-eebba453087f435b96b598c01a31a3f1
- Source dataset
- uspto-grants-2013_11
- Patent number
- US08586744B2
Reaction notes
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