HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2,2-Trifluoroethylamine hydrochloride → Ethanimidic acid, N-(2,2,2-trifluoroethyl)-, ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2,2-Trifluoroethylamine hydrochloride | HCID 9772 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethanimidic acid, ethyl ester, hydrochloride (1:1) | HCID 2724290 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethanimidic acid, N-(2,2,2-trifluoroethyl)-, ethyl ester | HCID 86618848 | 87.9% |
Reaction Steps
Ethyl acetimidate hydrochloride (1.23 g, 9.95 mmol) and 2,2,2-trifluoroethylamine hydrochloride (1.35 g, 9.95 mmol) were dissolved in CH2Cl2 (32 mL)/H2O (3.2 mL). K2CO3 (0.69 g, 4.98 mmol) was added and stirred for 30 minutes. The two layers were separated. The aqueous layer was extracted with CH2Cl2 (2×10 mL). The combined organic layer was dried with Na2SO4 and concentrated to give 1.48 g of N-(2,2,2-Trifluoro-ethyl)-acetimidic acid ethyl ester as a light yellow liquid in 87% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586744B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-5c7f881215214c66bdcb656600d685aa |
| Source note | uspto-grants-2013_11 |