HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(3-Carbamoyl-6-chloropyridin-2-ylamino)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 4-(3-carbamoyl-6-chloropyridin-2-ylamino)benzoate | HCID 57489609 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(3-Carbamoyl-6-chloropyridin-2-ylamino)benzoic acid | HCID 57489610 | — |
Reaction Steps
Methyl 4-(3-carbamoyl-6-chloropyridin-2-ylamino)benzoate was dissolved in 20 mL of MeOH, treated with 10 mL of 30% NaOH, and stirred at rt for 3 h. The reaction mixture was acidified with 1N HCl and the resulting solid was filtered and air dried to give 1.43 g of 4-(3-carbamoyl-6-chloropyridin-2-ylamino)benzoic acid as a yellow solid. LCMS: (M+H)+=292.06, 294.00 (Cl pattern).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586751B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-00b01ce3bd1d417d853c8ba16ec31ba4 |
| Source note | uspto-grants-2013_11 |