Hydrochloric Acid → HCID 57489627, compound

Participants

Reaction Steps

A mixture of powdered solid sodium hydroxide (121 mg, 3.04 mmol) in 1-propanol (10 mL) was stirred at rt until the solid material dissolved. Then 2,6-dichloro-4-(4-(morpholine-4-carbonyl)phenylamino)nicotinamide (600 mg, 1.518 mmol) was added and the mixture was stirred. The resulting suspension was placed in a heating block at 60° C. for 2 hrs. Next, the reaction mixture was cooled to rt and acidified with HCl (4 ml, 1N) and diluted with water. The cloudy precipitate was extracted into CH2Cl2 and concentrated to give 600 mg of light yellow solid. LCMS: (M+H)+=419.20, 421.19 (Cl pattern).

Provenance & Evidence