HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 86663706, compound → HCID 57489646, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 86663706 | HCID 86663706 | — |
| Reactant | HCID 86663707 | HCID 86663707 | — |
| Product | HCID 57489646 | HCID 57489646 | — |
Reaction Steps
The sample was separated on a chiral column: Chiralpak AS-H 25×3 cm, 5 μm; Column Temp. 40° C.; Flow rate: 150 mL/min; Mobile Phase: CO2/MeOH=65/35; to give the two enantiomers. Example 33: (R)-5-fluoro-2-(4-morpholinophenylamino)-6-(3-(3-thiazol-2-ylureido)cyclohex-1-enyl)nicotinamide and Example 440: (S)-5-fluoro-2-(4-morpholinophenylamino)-6-(3-(3-thiazol-2-ylureido)cyclohex-1-enyl)nicotinamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586751B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-15de1e5e8d254fda98885a88c7a8b917 |
| Source note | uspto-grants-2013_11 |