HuagongsheHuagongshe Chemistry Print Report · For research reference only
Picolyl chloride hydrochloride → 7-(2-tert-butoxypyridin-4-yl)-4-(pyridin-2-ylmethyl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Picolyl chloride hydrochloride | HCID 23392 | — |
| Reactant | 2-(tert-Butoxy)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine | HCID 45785993 | — |
| Reactant | 7-Bromo-2,3,4,5-tetrahydro-1,4-benzoxazepin-5-one | HCID 60124972 | — |
| Product | 7-(2-tert-butoxypyridin-4-yl)-4-(pyridin-2-ylmethyl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one | HCID 71183721 | — |
Reaction Steps
Compound VI-4 was prepared according to Example 36 using 7-bromo-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one, 2-tert-butoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine and 2-(chloromethyl)pyridine hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586732B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-7fe0b41d3a5b4bba90a044089ae38ab6 |
| Source note | uspto-grants-2013_11 |