HCID 71608063, compound → N-[(6-chloropyridin-3-yl)methyl]-2,2-difluoroethanamine

Participants

Reaction Steps

An amount of 2 g (7.38 mmol) of N-[(6-chloropyridin-3-yl)methyl]-N-(2,2-difluoroethyl)prop-2-en-1-amine is placed in 20 ml of n-butanol and treated with 100 mg of 10% palladium-on-charcoal (water-moistened). The mixture is subsequently stirred and heated at reflux for 18 h until complete conversion has been achieved. The reaction mixture is cooled to ambient temperature and then filtered through celite. The solvent is removed under vacuum. An amount of 1.3 g of N-[(6-chloropyridin-3-yl)methyl]-2,2-difluoroethanamine is obtained (corresponds to 84% yield).

Provenance & Evidence