Phenol → Phenyl 2-hydroxy-4,5-dimethoxybenzoate

Participants

Reaction Steps

In 10 g of xylene were suspended 1.0 g of compound (2a) and 522 ma of phenol, to which 460 μL of SOCl2 was then added dropwise before heating to reflux for 3 hours, followed by further adding 184 μL of SOCl2 and additionally heating to reflux for one hour. The reaction solvent was distilled off, followed by adding methanol to the residue before stirring. The precipitated crystal was collected by filtration to provide 880 mg of phenyl 2-hydroxy-4,5-dimethoxybenzoate (3a) at a yield of 64%.

Provenance & Evidence